Willock, who suffered an achilles injury last term, makes his first outing for United since April while Longstaff will also feature in the middle of the park.
Pope continues his place in-between the sticks while Emil Krafth and Dan Burn, captaining his boyhood club, are set to feature in the heart of Newcastle's backline, with Tino Livramento and Lewis Hall likely to start on the defensive flanks.
Joelinton is set to partner Willock and Longstaff in midfield, while Jacob Murphy - on target in Saturday's 2-0 win against Hull City - and Harvey Barnes will aim to provide attacking support for Alexander Isak, who broke the deadlock against the Tigers at the MKM Stadium last weekend.
Miguel Almirón has been named on the bench otherwise Howe has a number of youthful outfield options from the bench, including the likes of Ben Parkinson, Jay Turner-Cooke, Jamie Miley, Trevan Sanusi and Alfie Harrison, while Cathal Heffernan could make his first-team debut for Newcastle United today.
Odysseas Vlachodimos and John Ruddy are the substitute goalkeepers.
Newcastle United: Nick Pope, Tino Livramento, Emil Krafth, Dan Burn (c), Lewis Hall, Sean Longstaff, Joe Willock, Joelinton, Jacob Murphy, Harvey Barnes, Alexander Isak.
Substitutes: Odysseas Vlachodimos, John Ruddy, Cathal Heffernan, Jamie Miley, Alfie Harrison, Jay Turner-Cooke, Trevan Sanusi, Miguel Almirón, Ben Parkinson.
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