Bruno Guimarães' brace, capped with a 95th-minute winner, earned the Magpies a dramatic 2-1 victory over Leicester City on Sunday.
And head coach Howe has opted to keep faith with the same starting 11 that lined up for that triumph over the Foxes at St. James' Park, meaning the Brazilian international will once again partner compatriot – and matchday programme cover star – Joelinton in midfield.
In goal, Martin Dúbravka will be out for a clean sheet against the Eagles, just behind a back four of Emil Krafth, Fabian Schär, Dan Burn and Matt Targett.
The two Brazilians will provide some steel and energy in the middle of the park alongside stand-in skipper Jonjo Shelvey, while Allan Saint-Maximin and Miguel Almirón start out wide.
And Chris Wood will lead the line for United, who are looking for a sixth home win in succession for the first time since the 2003/04 season.
There is just one change on the Newcastle bench, with Javier Manquillo included among the substitutes at the expense of Paul Dummett.
Karl Darlow, Jamaal Lascelles and Federico Fernández are named, as are Jacob Murphy, Matt Ritchie and Sean Longstaff.
Dwight Gayle and Joe Willock – whose fine run created Guimarães' winner at the weekend – complete the list of substitutes named by Howe for the clash with Patrick Vieira’s men.
Newcastle United: Martin Dúbravka; Emil Krafth, Fabian Schär, Dan Burn, Matt Targett; Jonjo Shelvey, Bruno Guimarães, Joelinton; Allan Saint-Maximin, Chris Wood, Miguel Almirón.
Substitutes: Karl Darlow, Javier Manquillo, Jamaal Lascelles, Federico Fernández, Jacob Murphy, Matt Ritchie, Sean Longstaff, Joe Willock, Dwight Gayle.