It's the same team which won 3-1 at Southampton seven days earlier, with Jacob Murphy making his 200th appearance for the Magpies.
Howe - taking charge of his 700th career game - continues with Martin Dúbravka in goal, while Dan Burn lines up in defence against one of his former clubs.
United have won ten of their last 11 matches in all competitions, with Alexander Isak netting 12 goals in that sequence.
There's one change on the bench, with Miguel Almirón completing a move to Atlanta United during the week. Emil Krafth comes into the squad.
The other substitutes are Nick Pope, Kieran Trippier, Sven Botman, William Osula, Lloyd Kelly, Joe Willock, Sean Longstaff and Lewis Miley, who scored his first goal for Newcastle in this fixture last season.
Newcastle United: Martin Dúbravka, Fabian Schär, Joelinton, Sandro Tonali, Anthony Gordon, Alexander Isak, Lewis Hall, Tino Livramento, Jacob Murphy, Dan Burn, Bruno Guimarães
Substitutes: Nick Pope, Kieran Trippier, Sven Botman, Emil Krafth, William Osula, Lloyd Kelly, Joe Willock, Sean Longstaff, Lewis Miley