United head into the last-four tie at St. James' Park following a 2-0 away win against the Gunners in last month's first leg and Eddie Howe has opted to make two changes to the starting XI from last weekend's 2-1 home defeat against Fulham.
Trippier replaces Tino Livramento, who drops to the bench, and a change in formation could be likely this evening as Botman starts in place of the injured Joelinton.
The Dutchman will partner Fabian Schär, who missed United's first leg victory against Arsenal due to suspension, and Dan Burn at the heart of United's defence while Lewis Hall retains his place at full-back on the left flank. Martin Dúbravka maintains his place in-between the sticks.
Bruno Guimarães, who also missed last month's first leg against the North London outfit through suspension, captains the Magpies and will be situated alongside Sandro Tonali in the middle of the park.
Jacob Murphy and Anthony Gordon will aim to provide attacking support for Alexander Isak, who has scored twice in his last two appearances against the Gunners.
Callum Wilson is named in a matchday squad for the first time since December's Premier League clash at Brentford while midfield trio Joe Willock, Sean Longstaff and Lewis Miley all feature on the substitutes' bench.
William Osula, Emil Krafth and Matt Targett complete the bench while Nick Pope is the substitute goalkeeper.
Newcastle United: Martin Dúbravka, Kieran Trippier, Sven Botman, Fabian Schär, Sandro Tonali, Anthony Gordon, Alexander Isak, Lewis Hall, Jacob Murphy, Dan Burn, Bruno Guimarães (c).
Substitutes: Nick Pope, Callum Wilson, Matt Targett, Emil Krafth, William Osula, Tino Livramento, Joe Willock, Sean Longstaff, Lewis Miley.