Only Martin Dúbravka and Joelinton keep their places from the 2-0 Carabao Cup semi-final first leg win at Arsenal.
Sven Botman, Sandro Tonali, Anthony Gordon, Alexander Isak, Lewis Hall, Tino Livramento, Jacob Murphy, Joe Willock and Dan Burn all come out of the side.
But Fabian Schär returns from suspension and there's still a great deal of experience and quality in both the line-up which will take to the field for the 3pm GMT kick-off and the substitutes.
Dúbravka starts in goal with Kieran Trippier captaining the team and Schär joining the former England man in defence.
Matt Targett and Lewis Miley make their first starts of the season while teenage winger Trevan Sanusi is named among the substitutes for the first time in a competitive game.
Tonali, Gordon, Hall, Livramento, Burn and Guimarães are also options from the bench.
Newcastle United: Martin Dúbravka, Kieran Trippier (c), Fabian Schär, Joelinton, Harvey Barnes, Matt Targett, Will Osula, Miguel Almirón, Lloyd Kelly, Sean Longstaff, Lewis Miley
Substitutes: Odysseas Vlachodimos, Sandro Tonali, Anthony Gordon, Lewis Hall, Tino Livramento, Dan Burn, Alex Murphy, Bruno Guimarães, Trevan Sanusi