United hold a one-goal lead going into the second leg on Tyneside following last week's 1-0 win at St Mary's, and head coach Howe has opted to stick with the same side which gave the Magpies the advantage as they look to book their place in the Wembley final.
Nick Pope continues in goal, with Kieran Trippier, Fabian Schär, Sven Botman and Dan Burn forming a now-familiar backline.
Bruno Guimarães will anchor the side at the heart of United's midfield trio, with the energy and industry of Sean Longstaff and Joe Willock to the right and left of the Brazilian schemer.
And further forward, Miguel Almirón and Joelinton start on the flanks, with Callum Wilson leading the line at centre forward.
There's plenty of firepower on the bench, with Alexander Isak and Allan Saint-Maximin both named.
Karl Darlow provides cover in goal, while Jamaal Lascelles, Paul Dummett and Jamal Lewis are the defensive reinforcements.
Matt Ritchie, Elliot Anderson and Jacob Murphy complete the list of players available for Howe to deploy from the bench as United bid to reach a first major final in 24 years.
Newcastle United: Nick Pope; Kieran Trippier, Fabian Schär, Sven Botman, Dan Burn; Sean Longstaff, Bruno Guimarães, Joe Willock; Miguel Almirón, Callum Wilson, Joelinton.
Substitutes: Karl Darlow, Jamaal Lascelles, Paul Dummett, Matt Ritchie, Jamal Lewis, Elliot Anderson, Jacob Murphy, Allan Saint-Maximin, Alexander Isak.