The Magpies take on Ange Postecoglou's men looking to bounce back from Thursday's 3-0 defeat at Everton and though United's starting 11 is the same, there are signs that their recent injury nightmare is abating, with Callum Wilson and Sean Longstaff fit enough to return to the bench in North London.
Martin Dúbravka is in goal, with Kieran Trippier, Jamaal Lascelles, Fabian Schär and Tino Livramento forming a now-familiar back four.
Lewis Miley lines up in midfield along with Brazilian international duo Bruno Guimarães and Joelinton.
And Alexander Isak leads the line once more, with support from Miguel Almirón and Anthony Gordon on the flanks.
Wilson and Longstaff are the stand-out inclusions among the substitutes, with Emil Krafth, Paul Dummett and Lewis Hall also named.
Alex Murphy, Matt Ritchie and goalkeeping pair Loris Karius and Mark Gillespie complete the list of replacements available for Howe to call on in the capital.
Newcastle United: Martin Dúbravka; Kieran Trippier, Jamaal Lascelles, Fabian Schär, Tino Livramento; Lewis Miley, Bruno Guimarães, Joelinton; Miguel Almirón, Alexander Isak, Anthony Gordon.
Substitutes: Loris Karius, Mark Gillespie, Emil Krafth, Paul Dummett, Alex Murphy, Lewis Hall, Matt Ritchie, Sean Longstaff, Callum Wilson.