United saw off Brentford at St. James' Park in midweek and head to the King Power Stadium looking to further boost their hopes of Champions League qualification, with leading goalscorer Alexander Isak - who opened the scoring against the Bees - again set to spearhead Newcastle's attack against Ruud van Nistelrooy's men.
Nick Pope is in goal, with Kieran Trippier, Fabian Schär, Dan Burn and Tino Livramento lining up in defence.
Sandro Tonali - scorer of the winner in Wednesday night's victory - anchors the midfield, with captain Bruno Guimarães and Joelinton either side of the Italian international.
And Isak starts in attack, with Jacob Murphy and former Foxes winger Harvey Barnes on the flanks.
Joe Willock misses out on a place in the squad as the Magpies observe concussion protocols, while Anthony Gordon is not yet fit to return, meaning youngster Sean Neave retains his place on the bench alongside fellow forwards Callum Wilson and Will Osula.
Sean Longstaff and Lewis Miley are the midfield reinforcements, with Emil Krafth and Matt Targett acting as defensive backup. Martin Dúbravka and John Ruddy are the substitute goalkeepers.
Newcastle United: Nick Pope; Kieran Trippier, Fabian Schär, Dan Burn, Tino Livramento; Bruno Guimarães, Sandro Tonali, Joelinton; Jacob Murphy, Alexander Isak, Harvey Barnes.
Substitutes: Martin Dúbravka, John Ruddy, Emil Krafth, Matt Targett, Sean Longstaff, Lewis Miley, Will Osula, Callum Wilson, Sean Neave.