Longstaff replaces the injured Joe Willock in the middle of the park, one of two changes from the side which claimed a 4-1 win against Brighton & Hove Albion on Thursday night.
Fellow Geordie, Elliot Anderson, has been handed his second Premier League start of the 2022/23 season, with Joelinton - originally named in the starting line-up - suffering an injury in the warm-up of tonight's fixture.
Nick Pope continues in-between the sticks behind a four-man defence consisting of Kieran Trippier - making his 150th Premier League appearance this evening - as well as Fabian Schär, Sven Botman and Dan Burn.
Bruno Guimarães continues in central midfield while Miguel Almirón and Alexander Isak occupy the respective flanks, with Callum Wilson - making his 200th English top-flight appearance - leading the line.
Howe has a number of attacking options to deploy from the bench, including Allan Saint-Maximin, Anthony Gordon and Jacob Murphy, who sat out the Magpies’ win against Brighton last week, while 17-year-old Lewis Miley could be line for his senior debut if introduced this evening.
Harrison Ashby, who joined the Magpies from West Ham United in January, is named in a Magpies matchday squad for the first time while Paul Dummett, Matt Targett and Jamal Lewis have also been named on the substitutes’ bench.
Newcastle United: Nick Pope, Kieran Trippier (c), Fabian Schär, Sven Botman, Dan Burn, Sean Longstaff, Bruno Guimarães, Elliot Anderson, Miguel Almirón, Alexander Isak, Callum Wilson.
Substitutes: Martin Dúbravka, Harrison Ashby, Paul Dummett, Matt Targett, Jamal Lewis, Anthony Gordon, Jacob Murphy, Allan Saint-Maximin, Lewis Miley.