The January signings have each made one substitute appearance in the Premier League but are named in Rafa Benítez's starting XI after a week of training with their new team mates in Spain.
Jonjo Shelvey and Ciaran Clark are not involved, but every other player is likely to get some game time against the Russian side.
Karl Darlow starts in goal, with Barreca joined in defence by DeAndre Yedlin, Fabian Schär, skipper Jamaal Lascelles and Florian Lejeune.
Fit-again duo Mohamed Diamé and Ki Sung-yueng are in midfield, along with Kenedy, while Almirón is set to play behind main striker Salomón Rondón, who spent time in Russia with Rubin Kazan and Zenit Saint Petersburg.
The substitutes are Martin Dúbravka, Freddie Woodman, Paul Dummett, Matt Ritchie, Yoshinori Muto, Isaac Hayden, Ayoze Pérez, Federico Fernández, Javier Manquillo, Joselu, Christian Atsu and Sean Longstaff.
Newcastle United: Karl Darlow, DeAndre Yedlin, Fabian Schär, Jamaal Lascelles, Florian Lejeune, Antonio Barreca, Mohamed Diame, Ki Sung-yueng, Kenedy, Miguel Almirón, Salomón Rondón.
Substitutes: Martin Dúbravka, Freddie Woodman, Paul Dummett, Matt Ritchie, Yoshinori Muto, Isaac Hayden, Ayoze Pérez, Federico Fernández, Javier Manquillo, Joselu, Christian Atsu, Sean Longstaff.
