The Magpies will entertain Russell Martin's side, who gained promotion to the English top-flight last season after beating Leeds United in the Championship play-off final, on Saturday, 17th August, with the fixture set to take place at 3pm (BST).
United then travel to the Vitality Stadium the following weekend to take on AFC Bournemouth before welcoming Tottenham Hotspur to St. James' Park on 31st August.
Following an international break, September begins with a trip to Wolverhampton Wanderers and, after a venture to the capital to face Fulham, Eddie Howe's men conclude the month with the visit of Premier League champions Manchester City.
United will enter the Carabao Cup at the second round stage this season after narrowly missing out on European qualification, and their campaign in the competition will begin on or around Wednesday, 28th August.
Arsenal, West Ham United and Liverpool come to Tyneside in successive home fixtures between November and December and, following a first Premier League meeting in 22 years with newly-promoted Ipswich Town on Saturday, 21st December, United's Boxing Day fixture is at St. James' Park, against Aston Villa.
Howe's side travel to Manchester United on Sunday, 29th December and Newcastle's first league game of 2025 will be at away at Tottenham on Saturday, 4th January.
The Magpies will end their league campaign at home for the first time since 2019-20 when hosting Everton on Sunday, 25th May (kick-off 4pm BST).
You can sync Newcastle United's 2024/25 fixtures to your calendar here.
All dates are subject to change due to live television selections and could move from Saturday to Sunday due to clubs participating in the Europa League or Europa Conference League the preceding Thursday.
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