Ralph Hassenhuttl's side weren't great travellers last season, losing 11 of their 19 on the road, before beginning the new season with a 3-1 defeat to Everton at Goodison Park.
But it's Newcastle's home record against the Saints that makes even more promising reading for the Toon Army faithful ahead of Saturday's 3pm (BST) kick-off.
The guests have found St. James' Park to be a bit of a bogey ground with only one win here in 17 visits, 13 of which ended in home victories. Newcastle are also on a strong recent run against Saturday's opponents, winning the last four home matches in the head-to-head scoring 11 goals in the process.
With the stats in favour of the home side, Newcastle fans can snap up an exclusive offer from BoyleSports, who have enhanced a home win with over 1.5 goals in the match from 2/1 to 4/1 - a bet that has landed in each of Southampton's last four visits to St. James' Park.
Newcastle to win and over 1.5 goals (was 2/1) now 4/1! (18+)