Newcastle's youngsters, managed by Graeme Carrick, booked their place in the fourth round following a dramatic 3-2 away win against Charlton Athletic, with Ben Parkinson's brace and Johnny Emerson's winner sealing a valiant comeback victory at The Valley.
The young Magpies have been rewarded with a home encounter against seven-time winners Arsenal who thrashed Millwall 6-0 in round three.
Details for the cup tie, which must be played by Saturday, 21st January 2023, will be confirmed in due course.
For the 2022/23 tournament, players must have been born on or after 1 September, 2004 and before 1 September, 2007 to be eligible to feature in the FA Youth Cup.
The Toon teenagers have won the competition twice in the their history after lifting the cup for the first time in 1962 before a side involving Geordie midfielder Paul Gascoigne, won the trophy in 1985.
The young Magpies reached the fifth round of last year's competition, losing out to Blackpool, and reached the quarter-finals in 2020/21 before bowing out at the last eight stage against eventual winners Aston Villa.