The young Magpies make the short trip to Walkergate to face the Northern League division one outfit in 2020, with kick-off at the Lions' ground to take place at 7.30pm (GMT).
United last won the Senior Cup back in 2017, beating Benfield at the semi-final stages with a 3-0 victory at Whitley Park.
Newcastle's youngsters will bid to lift the trophy for a 38th time in 2020 following a semi-final defeat last term against eventual winners Morpeth Town, losing 2-0 to the current holders at Craik Park.
Northumberland Senior Cup quarter-finals:
Newcastle Benfield vs. Newcastle United U23
Whitley Bay vs. Morpeth Town
Bedlington Terriers vs. Blyth Spartans
North Shields vs. West Allotment Celtic