Neil Winskill's side make the long trip to East Anglia to face the Canaries, with kick-off due to take place at 7pm (GMT).
The young Magpies will be bidding to lift the trophy for a third time since the competition's formation in 1953 after triumphs in 1962 and 1985.
Newcastle's youngsters enjoyed an impressive run to the SuperCupNI final - formerly known as the Milk Cup - last summer before losing out to Valencia.
Both sides met each other at the fifth round stage of the tournament back in 2018, with Norwich securing their place in the last eight after a dramatic 4-3 encounter two years ago.