The Magpies booked their place in the last-16 following a 3-2 away win against Birmingham City last weekend courtesy of Joe Willock's brace and Callum Wilson's strike.
Their reward is a home tie against Brighton, who claimed a 2-1 win against Chelsea in round four, and it has been confirmed that the encounter with the Seagulls will take place on Sunday, 2nd March. Kick-off has been set for 1:45pm GMT.
The cup game will also be broadcast live on ITV1.
Any further details, including ticketing information, will be confirmed on newcastleunited.com in due course.