The Toon teenagers, one of 32 sides to enter the prestigious youth competition at the third round stage, will host their Os counterparts at Whitley Park, with kick-off set at 12pm (GMT).
The young Magpies will be aiming to win the trophy for a third time in the club's history after tasting success in 1962 before a side including Geordie midfielder Paul Gascoigne, lifted the cup in 1985.
United’s youngsters reached the quarter-finals of the competition in 2021 with a side involving Elliot Anderson, beating the likes of Huddersfield Town, Leeds United and Watford, before exiting at the hands of eventual winners Aston Villa at St. James' Park.